Be part of a global study to see whether an investigational medication can decrease the chance of HIV transmission through sexual contact.

About the Study

PURPOSE 2 is a clinical research drug trial evaluating Lenacapavir, an investigational medicine designed to reduce the chance of getting HIV through sex. Some participants who enroll in the study will receive the investigation drug, Lenacapavir, via injection every 6 months while the other participants will receive the FDA-approved oral medication Truvada. Study-related doctors’ visits, condition monitoring, and the study medicine will be provided to participants at no cost. You do not need health insurance to participate. To see if you qualify for this trial, complete the prescreening form below.



To be eligible for this study you must be:

  • At least 18 years old
  • Having sex with male partners
  • At risk for HIV
  • Unaware of HIV status
  • Not currently taking PrEP

What to Expect


Once you complete the prescreening and are determined to be eligible, you will be contacted by one of our clinical research coordinators for additional screening.

Initial Testing

After prescreening, you will visit the clinical research facility located at 433 Cherry Street in Macon, where an HIV test and other blood work will be done.


If you qualify for the treatment stage, you will receive a daily pill and an injection every 6 months. Of the injection and the pill, one will be the active drug and one will be placebo.

Extension Phase

After completion of the treatment stage, you may be invited to enroll in a long-term extension study where you will receive only the active drug.

Why Participate?

No Cost Treatment

You will receive drug treatment and monitoring from study staff and a School of Medicine faculty physician at no cost to you.


All study participants will receive a stipend at the end of each study visit. This stipend is meant to assist with study-related expenses such as travel costs.

Make an Impact

By participating in this study you will be contributing to the advancements in medical knowledge of the prevention of HIV through sexual contact.

Long-Term Treatment

All study participants who complete the treatment stage may be eligible to receive an active drug.

Pre-Screening Form

Complete this form to see if you qualify to participate in the Purpose 2 clinical trial. The information you provide is confidential and will be used only to determine your eligibility in this trial. Your information will not be shared.