Zhi-Qing Zhao, M.D., Ph.D.
Professor, Department of Physiology, Division of Basic Medical Science
Previous Institution: Emory University School of Medicine in Atlanta
Location: 1250 East 66th Street, Savannah, GA 31404
Research is primarily focusing on inflammatory mechanisms of ischemia/reperfusion-inducedmyocardial injury, cardioprotection with mechanical (preconditioning and postconditioning) and pharmacological interventions, and tissue repair viamodulation of extracellular matrix and endogenous stem cells after myocardial infarction.
Kin H, Wang N-P, Corvera J, Guyton RA, Vinten-Johansen J, ZhaoZ-Q. Inhibition of myocardial apoptosis by postconditioning is associated with attenuation of oxidative stress-mediated NFkB translocation and cytokine release. Shock 29:761-768, 2008
Mykytenko J, Reeves, J, Kin H, Zatta AJ, Jiang R, Guyton RA, Vinten-Johansen J, Zhao Z-O.Postconditioning reduces infarct size via mitochondrial KATP channel activation during 24 hours ofreperfusion. Basic Res Cardio 103:472–484,2008
Xi L, Bader M, Zhao Z-Q, Das A, Kukreja RC. Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2receptors gene knockout mice. Circulation118 (suppl 1):32-37, 2008
Halkos ME., Zhao Z-Q, KerendiF, Wang N-P, Jiang R, Schmarkey LS, Martin BJ, Quyyumi AA, Few WL,Kin H, Guyton RA, Vinten-Johansen J. Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in aporcine model of myocardial infarction.Basic Res Cardio 103, 6:525-536, 2008
Zhao Z-Q,Puskas JD., XuD, Wang N-P, Guyton RA, Vinten-Johansen J, Matheny R. Modulation of cardiac remodeling with acellular matrix emulsion isassociated with myofibroblast proliferation and angiogenesis via recruitingc-kit positive cells after myocardial infarction. J Am Coll Cardiol 55:1250-1261,2010
Zhao H-X, Wang X-L, Wang Y-H, Wu Y, Li X-Y, Lu X-P, Zhao Z-Q, LiuH-R. Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha. Basic Res Cardiol 105:109-118, 2010
Zhao Z-Q. Postconditioning in reperfusion injury: A status report (Invited review). Cardiovascular Drug and Ther 24:265-279, 2010
Granfeldt A,Jiang R, Wang N-P, Mykytenko J, Eldaif S, Deneve J, Zhao Z-Q, Guyton RA, Tønnesen E, Vinten-Johansen J. PMN inhibition contributes to cardioprotection by postconditioning. Acta Anaesthesiologica Scandinavica 56:48-56,2012
Wang Z-F, WangN-P, Harmouche S, Philip T, Pang X-F, Bai F, Zhao Z-Q. Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats. Basic Res Cardiol 108:318-332, 2013