Wei-Hsiung Yang, Ph.D.

Wei-Hsiung Yang, Ph.D.Associate Professor of Physiology
Savannah Campus

Office:  912-721-8203
Location:  1250 East 66th Street, Savannah, GA 31404
E-mail:  yang_w@mercer.edu

Education:

  • Ph.D.: Colorado State University (Physiology) (01/1998 - 08/2001)
  • M.S.: National Taiwan University (Physiology) (09/1992 – 06/1994)
  • B.S.: National Sun Yat-Sen University (Biology) (09/1988 – 06/1992)

 

Post-Doctoral Training:

  • Postdoctoral Training: University of Texas Southwestern Medical Center at Dallas (10/2001 - 08/2005)
  • Postdoctoral Training: University of Michigan School of Medicine (09/2005 - 04/2008)

 

Teaching interests and responsibilities:

Gastrointestinal module (Block 4 Module 1) (Medical School Year 2)
Hematology module (Block 4 Module 2) (Medical School Year 2)
Endocrinology module (Block 4 Module 3) (Medical School year 2)
Reproduction module (Block 4 Module 4) (Medical School Year 2)
Foundation of Medicine (Block 1 Module 1) (Medical School Year 1)

 

Professional Society Memberships

10/2003 - present        Active Member, American Association for Cancer Research (AACR)
04/2001 - present        Active Member, The Endocrine Society


Research interests and current projects:

The Yang lab focuses on (1) establishing the principle of tumor suppressors relay between FOX proteins and noncoding RNA; (2) investigating the function and mechanism of post-translational protein modifications; (3) identifying the cancer-causing genes and tumor-suppressive genes, targets, and pathways; (4) identifying novel regulators of p53 tumor suppressor; (5) investigating the cancer prevention through diet.


Journal Articles (since 2009)

2019

Wu L, Yi B, Wei S, Yao D, He Y, Naik G, Bea S, Liu X, Yang WH, Sonpavde G, Liu R, Wang L (2019) Losses of Foxp3 and Tsc1 accelerate prostate cancer progression through a synergistic transcriptional and post-translational regulation of c-MYC. (accepted by Cancer Research on 01/24/2019) (CAN-18-2049R2)

 

2018

Wang CM, Liu R, Wang L, Yang WH* (2018) FOXP3 activates SUMO-conjugating UBC9 gene in human MCF7 breast cancer cells. International Journal of Molecular Sciences 19(7). pii: E2036. (* corresponding author)

 

2017

Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, Yang WH, Cui R, Liu R, Wang L. (2017) MicroRNA-200c and 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Research 19(1):73.

Wang CM, Wang RX, Liu R, Yang WH* (2017) Jun dimerization protein 2 activates Mc2r transcriptional activity: role of phosphorylation and SUMOylation. International Journal of Molecular Sciences 18(2). pii: E304.   (* corresponding author)

 

2016

Zhang W, Yi B, Wang C, Chen D, Wei S, Guo RJ, Lu C, Nguyen LH, Yang WH, Lillard JW, Zhang X, Wang L, Liu R (2016) Silencing of CD24 enhances the PRIMA-1-induced mutant p53 restoration in prostate cancer cells. Clinical Cancer Research 22(10):2545-2554.

Meredith LJ$, Wang CM$, Nascimento L, Liu R, Wang L, Yang WH* (2016) The key regulator for language and speech development, FOXP2, is a novel substrate for SUMOylation. Journal of Cellular Biochemistry 117(2):426-438. ($ equally contributed to this work) (* corresponding author)

 

2015

Liu R, Yi B, Wei S, Yang WH, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu CG, Wang L (2015) FOXP3-microRNA-146-NF-?B axis and therapy for precancerous lesions in prostate. Cancer Research 75(8):1714-1724.

Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L (2014) FOXP3 controls an miR-146/NF?B negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Research 75(8):1703-1713.

 

2014

Wang CM, Liu R, Wang L, Nascimento L, Brennan VC, Yang WH* (2014) SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cells. International Journal of Molecular Sciences 15(6): 10233-10251. (* corresponding author)

 

2013

Wang CM, Liu R, Wang L, Yang WH* (2013) Acidic Residue Glu199 Increases SUMOylation Level of Nuclear Hormone Receptor NR5A1. International Journal of Molecular Sciences 14(11): 22331-22345. (* corresponding author)

Liu R, Li S, Yang WH, Wang L (2013) IPEX Syndrome, FOXP3 and Cancer. Journal of Syndromes 1(1): 1-7.

Wang CM, Yang WH*(2013) Loss of SUMOylation on ATF3 inhibits proliferation of prostate cancer cells by modulating CCND1/2 activity. International Journal of Molecular Sciences 14: 8367-8380. (* corresponding author)

Wang CM, Yang WH*(2013) De-SUMOylation on ATF3 enhances p53-ATF3 binding and trans-activation ofp53 responsive promoter but not p53 stability. The North American Journal of Medicine and Science 6(2):44-50. (*corresponding author) http://najms.net/wp-content/uploads/v06i02p044.pdf

Wang CM, Brennan VC, Gutierrez NM, Wang X, Wang L, Yang WH*(2013) SUMOylation of ATF3 alters its Transcriptional Activity on Regulation of TP53Gene. Journal of Cellular Biochemistry 114(3):589–598. (*corresponding author)

 

2012

Wang CM, Yang WH*(2012)Recent Progress of DeSUMOylation in Biological Processes: A Mini Review. The North American Journal of Medicine and Science 5(2):71-77. (*corresponding author) http://najms.net/wp-content/upload/v5i2p071.pdf

Brennan VC, Wang CM, Yang WH* (2012) Bitter melon (Momordica charantia) extract suppresses adrenocortical cancer cell proliferation through modulation of the apoptotic pathway, steroidogenesis, and insulin-like growth factor type1receptor/RAC-? serine/threonine-protein kinase signaling. Journal of Medicinal Food 15(4):325-334. (* corresponding author) ($equallycontributed to this work)

 

2011

Wang CM, Yang WH*(2011) Post-translational modifications of NR5A1. Journal of Biomedical and Bioengineering 2(1):31-36. (* corresponding author) http://bioinfopublication.org/viewhtml.php?artid=BIA0001069

 

2010

Yang WH*, Gutierrez NM, Wang L, Ellsworth BS, Wang CM (2010) Synergisitc Activation of the Mc2r promoter by FOXL2 and NR5A1 in Mice. Biology of Reproduction 83(5):842-851. (* corresponding author) (Category: Mechanisms of Hormone Action)

 

2009

Kim AC, Barlaskar FM, Heaton JH, Else T, Kelly VR, Krill KT, Scheys JO, Simon DP, Trovato A, Yang WH, Hammer GD (2009) In Search of Adrenocortical Stem and Progenitor Cells. Endocrine Reviews 30(3):241-263.

Xu B, Yang WH, Gerin I, Hu CD, Hammer GD, Koenig RJ (2009) Dax-1 and Steroid Receptor RNA Activator (SRA)Function as Transcriptional Coactivators for Steroidogenic Factor-1 in Steroidogenesis. Molecular and Cellular Biology 29(7):1719-34.

Yang WH, Heaton JH, Brevig H, Mukherjee S, Iniguez-Lluhi JA, Hammer GD (2009) SUMOylation Inhibits SF-1 Activity by Reducing CDK7 MediatedSerine203Phosphorylation. Molecular and Cellular Biology 29(3):613-625.

 

Recent Presentations (since 2008)

Emura N, Yang WH* (2017) SF1 regulates ATF3 expression. The Society for the Study of Reproduction's 50th Annual Meeting, Washington, DC, USA. July13-16. Abstract #167. (* corresponding author)

Wang CM, Yang WH* (2014) JDP2 Enhances Activation of the mouse Mc2r Promoter. The 16th International Congress of Endocrinology (ICE) and the Endocrine Society’s 96th Annual Meeting (ENDO), Chicago, IL, USA. June 21-24. Abstract #P1-MON-0388. (* corresponding author)

Wang CM, Brennan VC, Gutierrez NM, Wang X, Wang L, Yang WH*(2013) SUMOylation of ATF3 alters MC2R, NR5A1,STAR, and TP53 gene activities. The American Association for Cancer Research (AACR)'s 104th Annual Meeting, Washington, DC, USA. April 6-10. Abstract #763A. (* corresponding author)

Brennan VC, Wang CM, Yang WH*(2011) Bitter melon (Momordica charantia) extract suppresses adrenocortical cancer cell proliferation and growth through modulation of the cell cycle pathway and steroidogenic activity. The American Association for Cancer Research (AACR)'s102th Annual Meeting, Orlando, FL, USA. April 2-6. Abstract#5587. (*corresponding author)

Yang WH*, Gutierrez NM, Wang L, Ellsworth BS, Wang CM (2010) SUMOylation of FOXL2 Increases Synergistic Activation of the Mc2r promoterbyFOXL2 andNR5A1/SF1. The Endocrine Society's 92th Annual Meeting, San Diego, CA, USA. June 19-22. Abstract #P1-105. (* corresponding author)

Yang WH*, Gutierrez NM (2009) Antagonistic Regulation of StAR Gene Expression and Synergistic Regulation of Mc2R Gene Expression by FoxL2 and SF-1. The Society for the Study of Reproduction's 42nd Annual Meeting, Pittsburgh, PA, USA. July18-22. Abstract #343. (* corresponding author)

Xu, B, Yang WH, Gerin I, Hammer GD, MacDongald OA, Koenig RJ (2008) DAX-1 and Steroid Receptor RNA Activator (SRA) Function as Transcriptional Coactivators for Steroidogenic Factor-1. The Endocrine Society's 90th Annual Meeting, San Francisco, CA, USA. June 15-18. Abstract #P3-31.

Yang WH, Heaton JH, Brevig H, Iniguez-Lluhi J, Hammer GD (2008) SUMOylation Inhibits SF-1 Activity by Reducing CDK7 Mediated Ser203 Phosphorylation. The Endocrine Society's 90th Annual Meeting, San Francisco, CA,USA. June 15-18. Abstract#P1-612.

 

Yang Lab Alumni:

Addison Randolph (current position: Mercer University School of Medicine class 2021)

Joseph Snooks (current position: Mercer University School of Medicine class 2021)

Marshall Akin (current position: Mercer University School of Medicine class 2021)

Natsuko Emura (current position: Iwate University Ph.D. student)

Dana Marie Sylvertre (current position: Mercer University School of Medicine class 2019)

Caroline (Allie) Linaugh

Dr. Leslie Jane Meredith (Mercer University School of Medicine class 2017)

Leticia Nascimento (current position: Medical College of Georgia class 2021)

Kasey Price

Victoria Brennan (current position: University of Miami Medical School class 2019)

Ninoska Gutierrez