Angabin Matin, PhD
Education
- BS (Hons.), Biochemistry, National University of Singapore
- MS, Biochemistry, National University of Singapore
- PhD, Cancer Biology, University of Texas, Health Science Center at Houston
- Postdoctoral Study, Genetics, Case Western Reserve University
Research Interest
Dr. Matin’s research interests include cancer genetics and cancer cell biology. They have used genetically modified animal and cellular models to study the function and interaction of cancer susceptibility genes, specifically in germ cell tumors and colon cancers.
Selected Publications
- Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 435:360-4, 2005. PMCID: PMC1421521.
- Zhu R, Heaney J, Nadeau JH, Ali S, Matin A. Deficiency of Splicing Factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res 70(18):7264-72, 2010. PMCID: PMC2940986
- Nunez L, Mokkapati S, Yu C, Deng JM, Behringer RR, Matin A. Generation of a novel mouse strain with conditional, cell-type specific, expression of DND1. Genesis. 2019 Sep 12:e23335. doi: 10.1002/dvg.23335.
- Godavarthi J, Polk S, Nunez L, Shivachar A, Gliesinger NLG, Matin A. Splicing Factor 1 (SF1) deficiency reduces colon polyp incidence in ApcMin/+ mice. Biology (Basel). 2020 Nov; 9(11): 398. PMCID: PMC7697247
Click here to see the full list of Dr. Matin’s work.
Grants
- R01CA93754, NIH/NCI, Principal Investigator, Testicular Cancer Susceptibility Genes on Mouse Chr 19.
- R21CA186033, NIH/NCI, Principal Investigator, The genetics of SF1 (Splicing Factor 1) in cancers.
- R21CA175833, NIH/NCI, Principal Investigator, Use of DND1 to counteract miRNA function in cancers.