Kenneth I. Onyedibe, MBBS, PhD

Education

  • MS, Medical Microbiology and Virology, University of Jos
  • MBBS (MD), University of Ilorin College of Medicine
  • Postgrad Diploma, Infectious Diseases, London School of Hygiene & Tropical Medicine
  • PhD, Microbiology & Infectious Diseases, Purdue University
  • Residency & Fellowship, Clinical Microbiology, Jos University Teaching Hospital

Research Interest

Dr. Onyedibe’s research interest is in infection and outbreak control, drug discovery, antimicrobial resistance, and immune cell signaling. The goal of research in Dr. Onyedibe’s team is to find better and more effective ways to prevent, treat, and/or control multi-drug resistant and emerging infections. His current projects include antibiogram designs, interpretation and evaluation, studies of acute febrile illnesses in various age groups and locations including within Africa, and the development of novel antimicrobial agents using various methods, including proteomics and bioinformatics.

Selected Publications

  • Onyedibe, K. I., Mohallem R., Wang, M., Aryal, U. K., & Sintim H. O. (2023). Proteomic and phosphoproteomic analyses of Jurkat T-cell treated with 2’3’-CGAMP reveals various signaling axes impacted by cyclic dinucleotides. Journal of Proteomics 15;279:104869. doi: 10.1016/j.jprot.2023.104869
  • Onyedibe, K. I., Nemeth, A. M., Dayal, N., Smith, R. D., Ernst, R. K., Melander, R. J., Melander, C. and Sintim, H. O. (2023). Re-sensitization of multidrug resistant and colistin resistant Gram-negative bacteria to colistin by Povarov/Doebner-derived compounds. ACS infectious diseases. doi.org/10.1021/acsinfecdis.2c00417.
  • Dayal, N., Onyedibe, K. I., Gribble, W. M., & Sintim, H. O. (2022). Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. European Journal of Medicinal Chemistry, 240, 114550.
  • Naclerio, G. A., Abutaleb, N. S., Onyedibe, K. I., Karanja, C., Eldesouky, H., Liang, H., Dieterly, A. Aryal, U. K., Lyle, T., Seleem, M. N., & Sintim, H. O. (2022). Mechanistic Studies and In Vivo Efficacy of Oxadiazole-Containing Antibiotic. Journal of Medicinal Chemistry, 65(9):6612-30.
  • Onyedibe, K. I., Elmanfi, S., Hedrick, V., Aryal, U. K., Kononen, E., Gursoy, U. K. & Sintim H. O. (2022). Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP. Journal of Oral Microbiology, 14:1, 2003617.
  • Dramowski, A., Ong’ayo, G., Rehman, A., Whitelaw, A., Labi, A., Obeng-Nkrumah, N., Ndir, A., Magwenzi, M., Onyedibe, K., Wolkewitz, M. and de Kraker, M., (2021). Mortality attributable to third generation cephalosporin resistance in Gram-negative bloodstream infections in African hospitals–a multi-site retrospective study. JAC-Antimicrobial Resistance, 3(1),dlaa130
  • Onyedibe, K. I., Dayal, N. & Sintim H. O. (2021). SF5 and SCF3-substituted tetrahydroquinoline compounds as potent bactericidal agents against multidrug resistant persister Gram-positive bacteria. RSC Medicinal Chemistry, 12, 1879-1893.
  • Onyedibe, K. I., Shehu, N. Y., Pires, D., Isa, S. E., Okolo, M. O., Gomerep, S. S. & Egah, D. Z. (2020). Assessment of hand hygiene facilities and staff compliance in a large tertiary health care facility in northern Nigeria: a cross sectional study. Antimicrobial Resistance & Infection Control, 9(1): 30.
  • Opoku-Temeng, C., Onyedibe, K. I., Aryal, U. K. and Sintim, H. O. (2019). Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics. Journal of Proteomics, 202, 103368
  • Shittu, A.O.; Oyedara, O.; Abegunrin, F.; Okon, K.; Raji, A.; Taiwo, S.S.; Ogunsola, F.; Onyedibe, K. I., Elisha, G. (2012). A multicentre study on the characterization of methicillin-susceptible and-resistant staphylococci in Nigeria. BMC-Infectious Diseases 12: 286

Click here to see the full list of Dr. Onyedibe’s work.

Professional Involvement

  • American Association for the Advancement of Science
  • American Society for Microbiology
  • International Association of Medical Science Educators
  • Infectious Diseases Society of America
  • International Society for Infectious Diseases
  • West African College of Physicians

Contact Dr. Kenneth I. Onyedibe

onyedibe_ki@mercer.edu