David Gu, PhD

Gu, QihaiEducation

  • MS, Physiology, Tongji Medical University
  • MD, Medicine, Binzhou Medical College
  • Postdoctoral Study, Physiology, University of Kentucky

Research Interest

Dr. Gu’s research is in the area of respiratory physiology and neurobiology, and specifically neural control of breathing. Another interest of his is medical education research.

Selected Publications

  • Gu, Q., & Lee, L. Y. (2001). Hypersensitivity of pulmonary C fibre afferents induced by cationic proteins in the rat. The Journal of Physiology, 537(Pt 3), 887-897. https://doi.org/10.1111/j.1469-7793.2001.00887.x
  • Gu, Q., Kwong, K., & Lee, L.-Y. (2003). Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway. Journal of Neurophysiology, 89(4), 1985-1993. https://doi.org/10.1152/jn.00748.2002
  • Gu, Q., & Lee, L.-Y. (2006). Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats. The Journal of Physiology, 574(Pt 3), 867-876. https://doi.org/10.1113/jphysiol.2006.110312
  • Gu, Q., Lim, M. E., Gleich, G. J., & Lee, L.-Y. (2009). Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons. American Journal of Physiology. Lung Cellular and Molecular Physiology, 296(3), L453-61. https://doi.org/10.1152/ajplung.90467.2008
  • Gu, Q., & Lin, R.-L. (2010). Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. Journal of Applied Physiology (Bethesda, Md.-Ø: 1985), 108(4), 891-897. https://doi.org/10.1152/japplphysiol.01371.2009
  • Gu, Q., & Lee, L.-Y. (2010). Regulation of acid signaling in rat pulmonary sensory neurons by protease-activated receptor-2. American Journal of Physiology. Lung Cellular and Molecular Physiology, 298(3), L454-61. https://doi.org/10.1152/ajplung.00381.2009
  • Gu, Q., & Lee, L.-Y. (2011). Airway irritation and cough evoked by acid: from human to ion channel. Current Opinion in Pharmacology, 11(3), 238-247. https://doi.org/10.1016/j.coph.2011.04.005
  • Gu, Q., Vysotskaya, Z. V, Moss, C. R. 2nd, Kagira, M. K., & Gilbert, C. A. (2013). Calcium-sensing receptor in rat vagal bronchopulmonary sensory neurons regulates the function of the capsaicin receptor TRPV1. Experimental Physiology, 98(11), 1631-1642. https://doi.org/10.1113/expphysiol.2013.074633
  • Gu, Q. D., Moss, C. R. 2nd, Kettelhut, K. L., Gilbert, C. A., & Hu, H. (2016). Activation of TRPV4 regulates respiration through indirect activation of bronchopulmonary sensory neurons. Frontiers in Physiology, 7, 65. https://doi.org/10.3389/fphys.2016.00065
  • Gu, Q. D., Joe, D. S., & Gilbert, C. A. (2017). Activation of bitter taste receptors in pulmonary nociceptors sensitizes TRPV1 channels through the PLC and PKC signaling pathway. American Journal of Physiology. Lung Cellular and Molecular Physiology, 312(3), L326-L333. https://doi.org/10.1152/ajplung.00468.2016

To see a complete list of Dr. Gu’s work, click here.


  • Principal Investigator, Modulation of acid sensing in pulmonary C-fiber sensory nerves by protease-activated receptor-2, Scientist Development Grant, American Heart Association
  • Principal Investigator, Protease-activated receptor-2 and pulmonary C-neuron hypersensitivity, Biomedical Research Grant, American Lung Association
  • Principal Investigator, Pulmonary stresses in small cell lung cancer: neurogenic mechanisms, Parker B. Francis Fellowship in Pulmonary Research, The Francis Families Foundation
  • Co-investigator, Pulmonary stress induced by hyperthermia: role of airway sensory nerves, US Army Medical Research and Materiel Command (PI: Lee), Department of Defense
  • Co-Investigator, Chemosensitivity of tachykinin-containing lung afferents, R01 (PI: Lee)
    Funding Agency: National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)

Professional Involvement

  • American Heart Association (AHA) (2013-2017)
  • American Physiological Society (APS)
  • International Association of Medical Science Educators (IAMSE)
  • Society for Neuroscience (SFN) (2001-2014)

Contact Dr. David Gu