Jinoh Kim, PhD

EducationHeadshot of Jinoh Kim, PhD

  • B.S., Zoology, Seoul National University
  • M.S., Molecular Biology, Seoul National University
  • Ph.D., Biochemistry, University of Connecticut
  • Postdoctoral Study, Molecular and Cell Biology, University of California Berkeley

Research Interest

Dr. Kim’s laboratory investigates the roles of a subcellular membrane-bound compartment called endoplasmic reticulum (ER) with emphasis on protein secretion and ER homeostasis. Dr. Kim’s research is implicated in a skeletal disease, osteogenesis imperfecta, and a skeletal muscle disease, nemaline myopathy.

Selected Publications

  • Moretti, T., K. Kim, A. Tuladhar, and J. Kim. 2023. KLHL12 can form large COPII structures in the absence of CUL3 neddylation. Mol. Biol. Cell 34:br4.
  • Lu, C.-L., S. Ortmeier, J. Brudvig, T. Moretti, J. Cain, S. Boyadjiev, J. Weimer, and J. Kim. 2022. Collagen has a unique SEC24 preference for an efficient export from the endoplasmic reticulum. Traffic 23:81-89.
  • Lu, C.-L., and J. Kim. 2021. Craniofacial diseases caused by defects in intracellular trafficking. Genes 12:726.
  • Lu, C.-L., and J. Kim. 2020. Consequences of mutations in the genes of the ER export machinery COPII in vertebrates. Cell Stress & Chaperones 25:119-209.
  • Justice, C.M.*, J. Kim*, S.D. Kim, K. Kim, G. Yagnik, A. Cuellar, B. Carrington, C.-L. Lu, R. Sood, S.A. Boyadjiev, and A.F. Wilson. 2017. A variant associated with sagittal nonsyndromic craniosynostosis alters the regulatory function of a noncoding element. Am. J. Med. Genet. A. 173:2893-2897.
  • Garbes, L., K. Kim, A. Rieß, H. Hoyer-Kuhn,F. Beleggia, A. Bevot, M.J. Kim, Y.H. Huh, H.-S. Kweon, R. Savarirayan, D. Amor, P.M. Kakadia, K.O. Kagan, J. Becker, S.A. Boyadjiev, S. Bohlander, O. Semler, B. Wollnik, O. Semler, S. Bohlander, J. Kim* and C. Netzer*. 2015. Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta. Am.J.Hum.Genet. 96:432-439.
  • Kim S.D., J.L. Liu, T. Roscioli, M.F. Buckley, G. Yagnik, S.A. Boyadjiev, and J. Kim. 2012. Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. FEBS Lett. 586:1516-1521.
  • Kim, S.D., K.B. Pahuja, M. Ravazzola, J. Yoon, S.A. Boyadjiev, S. Hamamoto, R. Schekman, L. Orci, and J. Kim. 2012. The SEC23-SEC31 interface plays a critical role for export of procollagen from the endoplasmic reticulum. J. Biol. Chem. 287:10134-10144.
  • Boyadjiev S.A., S.D. Kim, A. Hata, C. Haldeman-Englert, E.H. Zackai, C. Naydenov, S. Hamamoto, R.W. Schekman, and J. Kim. 2011. Cranio-Lenticulo-Sutural Dysplasia associated with defects in collagen secretion. Clin. Genet. 80:169-176.
  • Kim, S.D., and Kim, J. 2008. Sequence analyses of presenilin mutations linked to familial Alzheimer’s disease. Cell Stress & Chaperones 13:401-412.

Grants

  • NIH R21 AR075939: “Dysregulation of the unfolded protein response of the ER in nemaline myopathy”. 09/01/2020 08/31/2023. Principal Investigator.
  • NIH R01 GM110373: “Pathogenesis of diseases caused by aberrant COPII megavesicle assembly”. 01/01/2015 – 12/31/2020. Principal Investigator.
  • NIH R01 NS082283: “Novel mechanisms for distal transport in developing and mature neurons”. 04/01/2014 – 03/31/2019. Co-Investigator.
  • NIH R01 DE016886: “Nonsyndromic craniosynostosis: phenotype/genotype study”. 09/01/2014 – 07/31/2017. Co-Investigator.
  • NIH R21 DE022419: “Characterization of the interplay between SEC23A and the MAPK signaling pathway”. 05/17/2012 – 04/30/2014. Principal Investigator.

Professional Involvement

  • The American Society for Cell Biology
  • Journal Reviewers: Biochemical Journal, European Journal of Neuroscience, Life Science Alliance, Protein Science, Science Advances, Scientific Reports, Traffic

Contact Dr. Jinoh Kim

kim_j@mercer.edu