Tse-Yu Chen, PhD
Education
- BS, Entomology, National Chung-Hsing University
- MS, Biochemistry and Molecular Biology, National Yang-Ming University
- PhD, Entomology, University of Florida
- Postdoctoral Associate, Infectious Diseases, Yale University
- Postdoctoral Scholar, Entomology, Pennsylvania State University
Research Interests
Dr. Chen’s lab investigates the molecular interactions between mosquitoes and viruses, with an emphasis on recognition pathways that influence infection and transmission. His research focuses on identifying mosquito receptors, immune regulators, and metabolic processes that determine vector competence for arboviruses. His lab also examines how host blood components shape vector physiology and viral infection dynamics. Ultimately, the goal is to translate these discoveries into innovative mosquito-centric strategies, such as targeted genetic modifications or vaccine-like approaches, to disrupt pathogen transmission at its source.
Selected Publications
- Chen, T. Y., Marín-López, A., Raduwan, H., & Fikrig, E. (2024). Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infection. Mbio, 15(11), e02433-24.
- Marin-Lopez, A., Huck, J. D., Esterly, A. T., Azcutia, V., Rosen, C., Garcia-Milian, R., Sefik, E., Vidal- Pedrola, G., Raduwan, H., Chen, T. Y., Arora, G., Halene, S., Shaw, A.C., Palm, N.W., Flavell, R.A., Parkos, C.A., Thangamani, S., Ring, A.M., & Fikrig, E. (2024). The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity. Science immunology, 9(98), eadk9872.
- Chen, T. Y., Raduwan, H., Marin-Lopez, A., Cui, Y., & Fikrig, E. (2024). Zika virus exists in enterocytes and enteroendocrine cells of the Aedes aegypti midgut. Iscience, 27(7).
- Chen, T. Y., Bozic, J., Mathias, D., & Smartt, C. T. (2023). Immune-related transcripts, microbiota and vector competence differ in dengue-2 virus-infected geographically distinct Aedes aegypti populations. Parasites & Vectors, 16(1), 166.
- Chen, T. Y., & Smartt, C. T. (2021). Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells. Parasites & Vectors, 14(1), 551.
- Chen, T. Y., Lee, Y., Wang, X., Mathias, D., Caragata, E. P., & Smartt, C. T. (2021). Profiling transcriptional response of dengue-2 virus infection in midgut tissue of Aedes aegypti. Frontiers in Tropical Diseases, 2, 708817.
- Chen, T. Y., Smartt, C. T., & Shin, D. (2021). Permethrin resistance in Aedes aegypti affects aspects of vectorial capacity. Insects, 12(1), 71.