Wayne Glasgow, PhD

Glasgow, WayneEducation

  • BS, Chemistry, Georgia Institute of Technology
  • PhD, Pharmacology, Vanderbilt University
  • Post-doctoral and Senior Staff Fellow, Molecular carcinogenesis, National Institutes of Health

Research Interest

Dr. Glasgow has studied the role of bioactive lipids in the regulation of cell proliferation, differentiation, and transformation. In particular, his research characterizes metabolites of arachidonic and linoleic acid as mediators of growth factor signal transduction with human breast, prostate, and colon cancer cells.  Specifically, he has examined how pharmacological modulation of these metabolic pathways may regulate the growth and metastatic potential of certain tumor cell types.

Selected Publications

  • Lu, Q., Chen, H., Senkowski, C., Wang, J., Wang, X., Brower, S., Glasgow, W., Byck, D., Jiang, S., and Li, J.  Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines.  Oncology Report 35: 163-170, 2016
  • Huang, T., Jiang, S., Qin, L., Senkowski, C., Lyle, C., Terry, K., Brower, S., Chen, H., Glasgow, W., Wei, Y., and Li, J.  Expression and diagnostic value of HE4 in pancreatic adenocarcinoma.  International Journal of Molecular Sciences 16: 2956-2970, 2015
  • Lu, Q., Li, J., Senkowski, C., Tang, Z., Wang, J., Huang, T., Wang, X., Terry, K., Brower, S., Glasgow, W., Chen, H., and Jiang, S.  Promoter hypermethylation and decreased expression of syncytin-1 in pancreatic adenocarcinomas.  PLOS One 10 (7): e0134412.doi:10.1371/journal.pne.0134412, 2015
  • Patel, N., Vogel, R., Chandra-Kuntal, K., Glasgow, W., and Kelavkar, U.  A novel three serum phospholipid panel differentiates normal individuals from those with prostate cancer.  PLOS One 9(3): e88841.doi:10:1371/journal.pone.008841, 2014
  • Patulu, H.S.K., Wang, D., Quyen, D.V., Singh, N.K., Kudumani-Sridharan, V., Karpurapu, M., Park, E.A., Glasgow, W.C., and Rao, G.N.  SRC-dependent STAT3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-HETE-induced vascular smooth muscle migration.  Journal of Biological Chemistry 284: 31142-31155, 2009
  • Moon, Y., Eling, T.E., and Glasgow, W.C.  Curcumin suppresses interleukin 1ÔÅ¢-mediated microsomal prostaglandin E synthase-1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways.  Journal of Pharmacology and Experimental Therapeutics 315:  788-795, 2005
  • Nony, P.A., Kennett, S.B., Olden, K., Roberts, J.D., and Glasgow, W.C.  15(S)-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through activation of TAK1, MKK6, and p38 MAPK.  Journal of Biological Chemistry 280:  31413-31419, 2005
  • Glasgow, W.C., Hui, R., Everhart, A.L., Jayawickreme, S., Angerman-Stewart, J., Han, B., and Eling, T.E.:  The linoleic acid metabolite, 13(S)-HpODE, augments the EGF receptor signaling pathway by attenuation of receptor dephosphorylation.  J. Biol. Chem. 272: 19269-19276, 1997

Professional Involvement

  • American Association for Cancer Research (AACR) on Educational Affairs
  • American Associates of Medical Colleges (AAMC)  Southern Group Georgia Cancer Coalition Advisory Review Committee
  • California Breast Cancer Research Program, Grant Review Committee for Molecular and Cell Biology Study Section
  • Department of Defense, Congressionally mandated research program, Breast Cancer Study Section
  • Tobacco-Related Disease Program, Grant Review Committee for General Biomedical Science Study Section

Contact Dr. Wayne Glasgow