Christy Bridges, PhD
Education
- BS, Biology, Berry College
- PhD, Cellular Biology, Medical College of Georgia
- Postdoctoral Fellowship, Department of Biochemistry & Molecular Biology, Medical College of Georgia
- Postdoctoral Fellowship, Department of Biomedical Sciences, Mercer University School of Medicine
Research Interest
Dr. Bridges’ laboratory studies the transport and toxicity of mercury. Her current projects include: the effects of toxic heavy metals on renal function in patients with chronic kidney disease, the effects of mercury-cyanide exposure on zebrafish, and the susceptibility of diabetic patients to heavy metal toxicity.
Selected Publications
- Pittman EH, D’Souza N, Mathis TN, Joshee L, Barkin JL, Bridges CC. Gender differences in the handling of inorganic mercury in aged rats. Curr Res Toxicol. 1:1-4 https://doi.org/10.1016/j.crtox.2020.02.003.
- Moss RF, George HS, Nijhara S, Orr SE, Joshee L, Barkin JL, Bridges CC. Chronic kidney disease in pregnant mothers affects maternal and fetal disposition of mercury. Reprod Toxicol 93: 137-145. PMID: 32084500
- Orr SE, George H, Barnes MC, Mathis T, Joshee L, Barkin J, Kiefer AM, Seney CS, Bridges CC. (2020) Co-administration of selenium with inorganic mercury alters the disposition of mercuric ions in rats. Biol Trace Elem Res. 195:187-195. PMID 31332705
- Kiefer AM, Seney CS, Boyd EA, Smith C, Shivdat DS, Matthews EJ, Hull MW, Bridges CC, Castleberry A. (2019) Chemical analysis of Hgo-containing Hindu religious items. PLoS ONE 14: e0226855. doi.org/10.1371/journal.pone.0226855 PMID: 31887195
- Mayorov V, Uchakin P, Amarnath V, Panov AV, Bridges CC, Uzhachenko R, Zackert B, Moore CS, Davies S, Dikalova A, Dikalov S (2019) Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation. Redox Biology 26:101300. PMID: 31437812
- Kamensky O, Horton D, Kingsley D, Bridges CC (2019) A Case of Accidental Mercury Poisoning. J Emerg Med. 56:275-278. PMID 30718027
- Orr SE, Barnes MC, Joshee L, Uchakina O, McKallip RJ, Bridges CC*. (2019) Potential mechanisms of cellular injury following exposure to a physiologically relevant species of inorganic mercury. Toxicol Lett. 304:13-20. PMID 30630035
- Orr SE, Barnes MC, George HS, Joshee L, Jeon B, Scircle A, Black O, Cizdziel JV, Smith B, Bridges CC* (2018) Exposure to mixtures of mercury, cadmium, lead, and arsenic alters disposition of single metals in tissues of Wistar rats. J. Toxicol Environ Health A..3:1-11. PMID 30507365
- Orr SE, Franklin CR, George HS, Nijhara S, Joshee J, Bridges CC* (2018) Pregnancy alters renal and blood burden of mercury in females. Biol Trace Elem Res. 186:9-11. PMID:29478229
- Orr SE, Joshee L, Barkin J, Bridges CC* (2018) Disposition of methylmercury over time in a 75% nephrectomized rat model. J Toxicol Environ Health A 81:349-360. PMID:29498598
Click here to see the full list of Dr. Bridges’ work.
Grants
- R15ES028915-A1A (NIH/NIEHS) Bridges (PI) 04/01/20 – 03/31/23 Uptake of Mercuric Species at Basolateral Membrane of Isolated Hypertrophied Proximal Tubules The purpose of this project is to determine which transport mechanisms on the basolateral membrane of proximal tubules are responsible for the enhanced uptake of mercuric species in hypertrophied proximal tubules.
- Navicent Health Foundation Bridges (PI) 10/01/16 – 09/30/18 Handling and Toxicity of Methylmercury in Pregnant Rats and Neonates The purpose of this project is to assess the effect of maternal exposure (prenatal and/or neonatal) to methylmercury on the developmental and behavioral aspects of fetuses.
- R15ES019991-01 (NIH/NIEHS) Bridges (PI) 01/01/11-12/31/14 Proximal Tubular Transport of Mercury and Effects of Reduced Renal Mass The purpose of this project was to utilize isolated perfused proximal tubules from uninephrectomized rabbits to assess the effects of cellular hypertrophy on the tubular transport of mercuric ions.
- R03ES015511-01 (NIH/NIEHS) Bridges (PI) 04/01/07-03/31/09 Role of Multidrug Resistance Proteins 2 and/or 4 in Renal Elimination of Mercury The purpose of this project was to assess the roles of Mrp2 and Mrp4 in the transport of mercuric ions from within proximal tubular cells into the tubular lumen.
- F32 ES012556-01 (NIH/NIEHS) Bridges (PI) 07/01/03-06/30/06 Mechanisms for Renal Uptake of Mercury The purpose of this project was to identify the mechanisms by which mercuric ions are taken up at the luminal membrane of proximal tubular cells
Professional Involvement
- Society of Toxicology, Member
- American Society of Pharmacology and Experimental Therapeutics, Member
- Sigma Xi, Member
- Toxicology Reports, Associate Editor
- Biochemical Pharmacology, Editorial Board Member
- Biological Trace Element Research, Editorial Board Member
- Journal of Toxicology and Environmental Health (Part A), Editorial Board Member
- International Journal of Molecular Sciences, Editorial Board Member