Himangshu Bose, PhD

Himangshu BoseEducation

  • MS, Organic Chemistry, University of North Bengal
  • PhD, Biophysical Chemistry, University of North Bengal
  • Postdoctorate, Molecular Cell Biology, Department of Health, Wadsworth Center
  • Fellowship, Cell Biology-Endocrinology, University of California San Francisco, Department of Pediatrics

Research Interest

Dr. Bose’s areas of interest include: reproductive endocrine cell biology and breast cancer. Most of his publications are highly cited in textbooks of endocrinology and biochemistry. Dr. Bose’s earliest discovery is a mandatory test (LCAH/LStAR) for all pregnant women after the first trimester and recently his laboratory has cloned a 22 kDa protein, SAM, which is likely to be a biomarker for breast cancer patients with high estradiol.

Selected Publications

  • Bose HS, Sugawara T, Strauss JF III, Miller WL: The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. New Engl J Med 335: 1970-1978, 1996 [Cited 625 (592+33) times]
  • Bose HS, Whittal RM, Baldwin MA, Miller WL: The active form of steroidogenic acute regulatory protein, StAR, appears to be a molten globule. Proc Natl Acad Sci USA 96: 7250-7255, 1999 [Cited 239 times]
  • Bose HS, Lingappa VR, Miller WL: Rapid regulation of steroidogenesis by mitochondrial protein import. Nature 417: 87-91, 2002 [Cited 323 times]
  • Bose M, Whittal RM, Miller WL, Bose HS*: Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and PCP. J Biol Chem 283: 8837-8845, 2008. [Cited 115 times]
  • Pawlak KJ, Prasad M, Thomas JL, Whittal RM, Bose HS*: Inner mitochondrial translocase Tim50 interacts with 3-beta hydroxysteroid dehydrogenase 2 (3bHSD2) to regulate adrenal and gonadal steroidogenesis. J Biol Chem 286: 39130-39140, 2011. [Cited 32 times]
  • Prasad M, Thomas JL, Whittal RM, Bose HS*: Mitochondrial 3-beta hydroxysteroid dehydrogenase enzyme activity requires a reversible pH-dependent conformational change at the intermembrane space. J Biol Chem 287: 9534-9546, 2012 [Cited 22 times]
  • Prasad M, Kaur J, Pawlak KJ, Bose M, Whittal RM, Bose HS*: Mitochondria associated ER-Membrane (MAM) regulates steroidogenic activity via StAR-VDAC2 interaction. J Biol Chem 290: 2604-2616, 2015 [Cited 81 times]
  • Rajapaksha M, Kaur J, Prasad M, Pawlak KJ, Perry EW, Marshall B, Whittal RM, Bose HS*: An outer mitochondrial translocase, Tom22, is crucial for inner mitochondrial steroidogenic regulation in adrenal and gonadal tissues. Mol Cell Biol 36: 1032-1047, 2016 [Cited 20 times]
  • Prasad M, Walker AN, Kaur J, Thomas, JL, Powel SA, Pandey AV, Whittal RM, Burak WE, Petruzzelli G, Bose HS*: Endoplasmic reticulum stress enhances mitochondrial metabolic activity. Mol Cell Biol 36: 3058-3074, 2016 [Cited 16 times]
  • Prasad M, Pawlak KJ, Burak WE, Perry EJ, Marshall M, Whittal RM, Bose HS*: Mitochondrial metabolic regulation by GRP78. Science Advances DOI:10.1126/sciadv.1602038, 2017 [Cited 25 times]
  • Bose HS*, Gebrail F, Marshall B, Perry EW, Whittal RW: Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis. Mol Cell Biol 39: DOI: 10.1128/MCB.00484-18. [Cited 3 times]
  • Bose HS*, Marshall M, Debnath DK, Perry EJ, Whittal RM: Electron Transport Chain Complex II regulates steroid metabolism. iSCIENCE, doi.org/10.1016/j.isci.2020.101295
  • Bose HS*, Whittal RM, Wheeler BW, Lanier CE, Marshall M, Rajapaksha M, Carbo ND, Hann EM, Perry EW, Hall NM, Melomed, MM, Perkins EL, Burak WE: Regulation of estradiol synthesis by aromatase interacting partner (AIPB). Mol Cell Biol 11: DOI 10.1128/MCB.00357-21

Grants

  • NIH K01: DK02762; “Structure and action of steroidogenic acute regulatory proteins”. From April 1, 2000 to March 31, 2003; $268,000. Principal Investigator. Highest score 1.09 percentile.
  • Pfizer, INC: “Mechanism of action of steroidogenic acute regulatory protein (StAR)”. $100,000. From July 2003 to June 2005. Principal Investigator. 2nd Highest Score
  • March of Dimes “Mechanism of import of steroidogenic acute regulatory protein (StAR)”. Research Faculty Award (RFP), $179,000. From June 1, 2004 to October 31, 2009. Principal Investigator.
  • “Mechanism of cholesterol and StAR transport into mitochondria”. $240,000. From July 1, 2004 to June 30, 2009. Principal Investigator. Highest score in the history of American Heart Association.
  • Florida Department of Health “Molecular mechanism of nicotine effect on reproductive function”. $441,000. From August 2004 to July 2007. Principal Investigator.
  • NIH R01: RHD057876; “Mechanism of action of steroidogenic acute regulatory protein (StAR)”. Principal Investigator. Grant percentile score was 0.4 and ranked highest in NICHD, awarded $1,077,500.00 (Direct)/ $1,677,593 (Total). From February 1, 2009 to January 31, 2016.
  • Anderson Cancer Ins. “Mechanism of action of aromatase”. $572,000. From September 1, 2011 to December 31, 2016. Principal Investigator.

Professional Involvement

  • American Heart Association (AHA) Southern Affiliates
  • European Journal of Immunology, Reviewer
  • Frontiers, Endocrinology Diabetes and Metabolism, Reviewer
  • German-Israeli Foundation
  • Indian Journal of Medical Research, Reviewer
  • International Journal of Biological Macromolecules, Environmental Toxicology Pharmacology, Molecular and Cellular Endocrinology, Reviewer
  • Italian Science and Technology
  • Journal of Biochemical and Molecular Toxicology, Life Sciences, Reviewer
  • Journal of Clinical Endocrinology and Metabolism, Reviewer
  • Journal of Endocrinology, Molecular Carcinogenesis, Molecular Medicine, Reviewer
  • Journal of Membrane Biology, Reviewer
  • Journal of Molecular Biology, Reviewer
  • Journal of Steroid Biochemistry and Molecular Biology, Reviewer
  • Journal of Theoretical Biology, Reviewer
  • National Institute of Child Health and Human Development (NICHD)/National Institutes of Health (NIH)
  • Polish National Science Centre
  • Public Library of Science (PLoS) one, Reviewer
  • Welcome Trust

Contact Dr. Himangshu Bose


bose_hs@mercer.edu